Main projects

    • Physics-informed ML
    • Industry and engineering
    • Ongoing

    AI for materials characterisation

    Physics-informed machine learning models for the prediction of the properties of industrial materials, in a research mandate with an international manufacturing company.

    2025–2027 · Industrial research mandate

    • Physics-informed ML
    • Causal AI and graphical models
    • Healthcare

    PRAESIIDIUM

    Patient digital twins that combine differential equation models of glucose metabolism with clinical and wearable data, to predict individual risk and suggest personalised interventions.

    2023–2025 · Horizon Europe consortium

    • Federated learning
    • Healthcare
    • Life sciences

    SPEARHEAD

    Machine learning models trained across Swiss hospitals without exchanging patient-level data, to support clinicians in the appropriate use of antibiotics for urinary tract infections.

    2022–2025 · Innosuisse Flagship consortium

    • Healthcare

    Early identification of ventilator-associated pneumonia

    A prospective cohort study and machine learning models that support the early diagnosis of ventilator-associated pneumonia, using data recorded continuously and automatically by mechanical ventilators.

    2023–2025 · Innosuisse

    • Life sciences
    • Healthcare

    K-CLIER

    Transfer learning from single-cell atlases to bulk transcriptomic data, producing low-dimensional representations that can be interpreted in terms of kidney cell states.

    2021–2022 · EOC

Other projects

    • Causal AI and graphical models
    • Healthcare
    • Ongoing

    Counterfactual image editing

    Generative models with a causal structure that predict how the radiological presentation of pulmonary oedema in intensive care patients would change under a different fluid therapy.

    IRCCS Humanitas Research Hospital

    • Causal AI and graphical models
    • Healthcare
    • Ongoing

    Emulation of clinical trials with real-world data

    Target trial emulation on routinely collected intensive care data, to estimate the effect of prone positioning on mortality and how this effect varies across patients.

    EOC, SUPSI MeDiTech

    • Healthcare

    GUIDE

    Interpretable, personalised insights on glucose management during physical activity for people with type 1 diabetes, combining machine learning with large language models.

    2024–2025 · Innosuisse Innovation Cheque · Enhance-d

    • Healthcare

    MitraL-AI

    A machine learning score that predicts all-cause mortality up to 48 months after transcatheter edge-to-edge repair of the mitral valve, to support shared decision-making between clinicians and patients.

    2023–2025 · EOC, USI

Earlier projects

    • Healthcare

    HEAVEN 2023 · Inselspital, Bern University Hospital

    Machine learning models to identify patients at high risk of difficult intubation.

    • Healthcare

    Life-ON 2021 · EOC

    Risk and diagnosis assessment strategies for perinatal depression.

    • Healthcare

    SpineReg 2020–2021 · IRCCS Ospedale Galeazzi, Milan

    Machine learning for patient stratification after lumbar spine surgery.

    • Industry and engineering

    Client analytics and natural language processing 2018–2021 · A major Swiss bank

    Direct mandates on churn analysis, client risk prediction, task-agnostic client representations and quality of client interactions through NLP.

    • Environment and society

    ALBIS 2018 · SUPSI

    Integrated system for the risk-based surveillance of the invasive mosquito Aedes albopictus in Switzerland.

    • Causal AI and graphical models

    Statistical learning and inference on big data with probabilistic graphical models 2016–2018 · Swiss National Science Foundation (SNSF)

    Hierarchical Bayesian estimation of the parameters of Bayesian networks.

    • Environment and society

    Data mining for public statistics 2016 · Cantonal statistical office

    Analysis of employment data for the official statistics of Canton Ticino.

    • Environment and society

    Climate change impact on debris-flow hazard 2015 · An engineering company

    Software for the prediction of debris-flow hazard in the Ticino region.